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Role of multidrug resistance protein 1 (MRP1) and glutathione S-transferase A1-1 in alkylating agent resistance

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This overview covers the main reasons to avoid them, drawing from Australian guidelines and studies, plus what to do if you're unsure

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Research Mechanism (Mechanism of Action) NNMT normally catalyses the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide (1-MNA)

weight loss by people not meeting guidelines), and safety/ethical issues, especially in direct-to-consumer contexts