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Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes (SUSTAIN-6) New England Journal of Medicine In 3,297 patients with T2D, semaglutide reduced major adverse cardiovascular events by 26% versus placebo over 2.1 years (HR 0.74), driven by 39% stroke reduction and 26% nonfatal MI reduction
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Patients with pre-existing gastrointestinal conditions should maintain closer monitoring
It holds water in the intestinal lumen, counteracting the increased water absorption that comes with extended transit time
However, its equally important to recognize what these medications cannot do
coli from adhering to the bladder wall, which is the critical first step in infection establishment
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