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Reinforcing this, in heart failure with preserved ejection fraction, randomized trials such as the STEP-HFpEF program published in the New England Journal of Medicine demonstrated improvements in symptoms and physical limitations, with benefits that could not be fully explained by weight loss alone
Structure visualization and analyses were carried out with UCSF Chimera (version 1.11.2) 88 , UCSF ChimeraX (version 1.7.1) 91 and PyMOL (version 3.0.3
Male rodents are frequently used in the VPA-induced ASD model because male animals often display more consistent behavioral alterations in this model (Kazlauskas et al., 2019
Each subject received in a random order a single subcutaneous dose of 1.2 mg liraglutide and placebo at an interval of 48 h, with subsequent clinical follow-up in the metabolic ward, during which blood pressure was monitored for the following 24-h and 24 h urinary samples were collected to assess sodium excretion
A portion of that group had their body composition assessed by dual-energy X-ray absorptiometry to determine if weight loss is caused by a reduction in fat loss prompted by the treatment
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