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37-study meta-analysis, 3,048 patients)
Discontinuation due to factors typically irrelevant in clinical trial settings (i.e., cost or insurance-related issues and medication shortages) could contribute to the substantial discrepancy between discontinuation rates in pivotal phase 3 trials and those reported in real-world studies. Regarding discontinuation due to side effects, Gasoyan says we do not currently know of patient-level predictors that would help identify who might experience side effects and why
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89 Under nutrient-replete conditions, acute GPX4 inhibition induces morphologically heterogeneous ferroptotic death phenotypes, in which necrotic-like, apoptotic-like, and mixed phenotypes coexist within the same cell population (Fig
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