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Most successful protocols involve verified deficits of 300500 calories daily, protein intake of 1.62.0 grams per kilogram of body weight, and adequate hydration (2.53 litres daily)

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AMPK phosphorylates various transcription factors (or cofactors) that serve as key regulators of biosynthetic pathways and metabolism

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An essential role in these biochemical processes might also be played by nicotinamide adenine dinucleotide phosphate, flavin mononucleotide, or flavin adenine dinucleotide [106]