The side effects of semaglutide are typically mild especially when compared to the complications associated with overweight and obesity
Since these drugs are still relatively new, there are still a lot of unknowns regarding the long-term effects of using these drugs
On the 12mg maintenance dose, participants lost an average of 28.7% of body weight versus 2.1% on placebo, as reported by Eli Lilly in December 2025 (peer-reviewed publication pending)
Kauko A, Engler D, Niiranen T, Ortega-Alonso A, Schnabel RB (2024) Increased risk of dementia differs across cardiovascular diseases and types of dementiadata from a nationwide study
2022;240:284-291.e9
The out-of-pocket costs can be offset by location, pharmacy, and eligibility for savings and assistance programs