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Several distinct MAPK subfamilies have been characterized in cardiac tissue, including the p38 MAP kinase, the stressed-activated protein kinase/c-Jun N-terminal kinase (JUN kinase), the extracellular-responsive kinase (ERKS), big MAPK-1(ERK5) [48]

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Acetyl-L-carnitine activates the peroxisome proliferator-activated receptor- coactivators PGC-1/PGC-1-dependent signaling cascade of mitochondrial biogenesis and decreases the oxidized peroxiredoxins content in old rat liver

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