SGLT2 inhibitors during pregnancy Animal None of the SGLT2 inhibitors showed developmental toxicity when a dose not resulting in maternal toxicity was administered during the interval coinciding with the first trimester period of organogenesis except for canagliflozin, where ossification delays of the metatarsal bones were seen ( Table 2 )
Sustainable weight management still depends on diet, physical activity, sleep, and treatment of contributing conditions when present
To those who are still bleating that we should keep trying diet and exercise before resorting to use of anti obesity medications or that we can maintain long term weight loss effected by use of medication by ceasing medication and relying on diet and exercise alone- please look up all the research which shows that lifestyle intervention alone can only effect 5-7% weight loss and this weight will also be regained in the next year or two
Your healthcare team should regularly review your complete medication regimen to optimise treatment whilst minimising adverse effects
Pain 161 , 6173 (2020)
MHRA Guidance on Unregulated Weight Loss Compounds The MHRA advises only obtaining medicines from GPhC-registered pharmacies, warns against 'research chemical' products intended for human use, and works with Border Force to intercept illegal medicine imports