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There are certain groups of patients whom we would not be initiating a GLP1-RA in patients with personal or family history of medullary cancer or multiple endocrine neoplasia syndrome type 2

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[2] The concept behind transdermal GLP-1 delivery involves using a patch applied to the skin that would theoretically release medication through the dermal layers into systemic circulation

Interoceptive stress activates glucagon-like peptide-1 neurons that project to the hypothalamus