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Contact your GP, prescribing clinician, or clinical trial team if: Cold feelings are persistent, worsening, or significantly affecting your quality of life You notice cold sensations accompanied by unusual fatigue, pallor, shortness of breath, or dizziness , which may suggest anaemia your GP can arrange a Full Blood Count (FBC) and ferritin level to investigate You experience cold, numb, or discoloured fingers and toes (particularly white, blue, or red colour changes), which could indicate Raynaud's phenomenon a condition affecting blood flow to the extremities (NHS) You have unexplained hair loss alongside cold intolerance , which may point to thyroid dysfunction a Thyroid Function Test (TFT) can be arranged by your GP Cold feelings develop alongside significant muscle weakness or cramps , which could suggest an electrolyte imbalance your GP can arrange Urea and Electrolytes (U&Es) and other relevant blood tests You experience persistent vomiting, diarrhoea, or an inability to keep fluids down , as these can lead to dehydration and, in some cases, acute kidney injury (AKI) seek prompt medical review if you notice reduced urine output or feel faint If you are enrolled in a clinical trial , contact your study team before making any changes to your treatment or if you develop new or worsening symptoms
Effects of sitagliptin and metformin treatment on incretin hormone and insulin secretory responses to oral and isoglycemic intravenous glucose
2020;105(4):dgaa061
A gradual titration schedule is commonly used to help reduce initial discomfort and improve adaptation
At 72 weeks on the top 36 mg dose, patients lost an average of 12.4% of body weight about 27.3 pounds compared with 0.9% in the placebo group
The best part, its not a trend
