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Ascorbate is the cofactor for Cu + dependent monooxygenases and for several 2-oxoglutarate and Fe 2+ dependent dioxygenases (2OG-oxygenases)
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Carcinogenesis, Mutagenesis, Impairment of Fertility
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One pivotal trial followed patients taking 600mg of racemic ALA daily for four years and found no significant safety concerns.7 We explore the differences between racemic ALA and R-ALA later in the guide, but its worth noting here: racemic ALA has the strongest long-term safety data in humans
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