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The excess production of reactive oxygen species (ROS) could be a predominant feature not only determined the cell death but also the cell death modalities [4]

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Atomic coordinates have been deposited in the Protein Data Bank (PDB) under accession codes 9PMD (OCTN2 inward-facing), 9PDQ (OCTN2 occluded) and 9PFB (OCTN2 ipratropium)

The results showed sustained benefit as long as participants continued treatment

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