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Mechanistically, GLP-1 signaling suppresses M1-associated genes while enhancing that of M2-related genes through activation of signal transducer and activator of transcription 3 (STAT3) (Wan and Sun, 2019)

The more risk factors documented, the stronger the case

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Anti-inflammatory effects of haptoglobin on LPS-stimulated macrophages: role of HMGB1 signaling and implications in chronic wound healing

519,520,521 Chronic inflammation, coupled with aberrant mechanisms of tissue repair and remodeling, contributes to the pathogenesis of tissue fibrosis

( A ) Flow cytometry of BODIPY-C11 stained CSE-depleted HeLa cells following treatment with RSL3 (5 M) for 4 h (left panel)