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Diabetes Care 33 , 23492354 (2010)
The antibody Fab7F38 appears to function by providing enhanced soluble surface area for crystal lattice packing, and indeed Fab7F38-bound GLP-1R can also assume an active conformation as shown by EM studies (see below), suggesting that Fab7F38 does not interfere with the conformational flexibility of the ECD during crystallization
Some may prioritize rapid appetite control, while others focus on measurable weight loss or hemoglobin A1c reduction
