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It may be important to include measurements of biomarkers of oxidative damage (e.g., products of DNA and lipid oxidation, such as 8-hydroxy-2-deoxyguanosine, 8-OHdG, or F 2 -isoprostanes) in observational studies, suggesting that the therapeutic benefit may actually be associated with an antioxidant effect (Moosmann and Behl, 2002

Phloretin suppresses carbohydrate-induced GLP-1 secretion via inhibiting short chain fatty acid release from gut microbiome

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This distinction matters because abnormal glucose, liver enzymes, kidney markers, lipids, or nutritional markers may predate semaglutide use

Diebold J et al

Lenzi A, Gandini L, Picardo M, Tramer F, Sandri G, Panfili E