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These findings highlight that GLP-1-RA such as Ex-4 can promote hMSC proliferation, while native GLP-1 forms and Liraglutide predominantly exert inhibitory effects on proliferation and glucose uptake, with varying results under different conditions, highlighting their context-dependent role in hMSC behavior and metabolic regulation

doi: 10.3389/fphar.2025.1610512 Received 12 April 2025 Accepted 15 May 2025 Published 30 May 2025 Volume 16 - 2025 Edited by Karuna Rasineni, University of Nebraska Medical Center, United States Reviewed by Asher Rajkumar Rajan, University of Nebraska Medical Center, United States Akash Batta, Dayanand Medical College & Hospital, India Updates Copyright 2025 Li, Huang, Wang, Huang, Luo and Huang

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Gilbert was lead author on a set of clinical guidelines from the American College of Cardiology in 2025 that recommend providers consider GLP-1s as a first-line treatment option for weight management in patients with obesity to reduce cardiovascular risk