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Research on postmenopausal women with overweight/obesity have indicated that those who used GLP-1 RAs combined with HRT experienced greater total body weight loss compared to those using GLP-1 RAs alone, suggesting that restored estrogen levels may enhance the metabolic efficacy of the GLP-1 medications

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Beyond these fundamental roles, mitochondria are deeply involved in cancer cell survival, immune evasion, tumor progression, and the development of drug resistance, particularly under the hypoxic conditions of the tumor microenvironment (TME) 8,9

Mild redness and slight swelling at the injection site are normal immune responses

Patients with a personal history of medullary thyroid carcinoma should never receive Zepbound, as the theoretical risk of tumor recurrence or progression outweighs any potential benefits