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A 2018 review identified several demonstrated capabilities of GHK-Cu: Research from 2015 noted that GHK-Cu may stimulate collagen production, regulate the skin remodeling process, attract immune cells to injury sites, and restore replicative vitality to fibroblasts (cells that help form connective tissue) in patients whove undergone radiation therapy for cancer

Common reported effects in clinical use include mild injection site reactions with subcutaneous administration, occasional digestive changes when taken orally, and rare reports of fatigue or dizziness

This persistent immune suppression not only dampens T-cell activity but also diminishes the overall effectiveness of ICIs

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The current evidence base is constrained by small sample sizes, heterogeneous study populations (e.g., inclusion of ACLF subgroups), and variability in FMT protocols (donor selection, delivery method, dosing)