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It has been proven to reduce oxidative stress and cartilage deterioration which are a normal consequence of ageing
10.3389/fphys.2015.00397 54 FilipekP
Similar antioxidant mechanisms were observed in our ischemia-reperfusion (IR) injury model, where bromelain restored oxidative balance through reductions in TOS and OSI and by increasing TAS
Although innovations such as vascularization, genome editing, omics-techniques, high-content imaging (HCI), machine-learning-based and automated systems are already a reality in organoids, protocols need to continue evolving to improve tissue communication, cell patterning signals, body axis simulation and spatial-temporal control of differentiation (Lokai et al., 2023)
The largest share still originates from the Zagreb group, but independent contributions have accumulated notably a body of in vitro tendon-fibroblast work from investigators at Chang Gung University in Taiwan beginning in the 2010s [6], and, more recently, systematic pharmacokinetic characterization
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