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Back to Journals Clinical Interventions in Aging Volume 11 Efficacy of L-carnitine supplementation on frailty status and its biomarkers, nutritional status, and physical and cognitive function among prefrail older adults: a double-blind, randomized, placebo-controlled clinical trial Authors Badrasawi M , Shahar S, Zahara AM, Nor Fadilah R, Singh DKA Received 21 May 2016 Accepted for publication 17 June 2016 Published 17 November 2016 Volume 2016:11 Pages 16751686 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Richard Walker M Badrasawi, 1,2 Suzana Shahar, 1 AM Zahara, 1 R Nor Fadilah, 3 Devinder Kaur Ajit Singh 4 1 Dietetic Programme, School of Healthcare Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia

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Average fat mass reduction across reviewed trials was under 1% compared to lifestyle advice alone

Following subcutaneous administration in clinical models: Both components demonstrate prolonged absorption with peak plasma concentrations occurring 24-72 hours post-injection GLP3 exhibits approximately 6-day half-life enabling once-weekly dosing Cagrilintide demonstrates 120-165 hour half-life (5-7 days) suitable for weekly administration Lipid conjugation of both peptides enables albumin binding and extended systemic circulation Distribution patterns show systemic exposure with concentration in metabolically active tissues The fatty diacid modifications on both peptides (C20 for GLP3 , eicosanedioic acid for cagrilintide) serve as albumin-binding moieties that dramatically extend plasma residence time compared to native peptides

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