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The first is extracellular matrix biology, where fibroblast culture and rat wound-chamber studies from the Maquart and Simeon groups (1988-2000) reported stimulation of collagen synthesis, sulfated glycosaminoglycan synthesis and small proteoglycan expression, alongside upregulation of matrix metalloproteinase-2 and its tissue inhibitors, a simultaneous increase in both matrix deposition and matrix turnover

LDSC is a statistical method that accurately assesses genetic correlation using data from GWAS, unaffected by biases due to sample overlap [25]

however, experts expressed the opinion that more studies are required (Figure 5)

First, the expression of GLP-1R remains controversial in many types of cells and tissues due to the lack of specific antibody against GLP-1R

GLP-1 provides powerful appetite suppression through brain receptors

Central GLP-1R signaling plays a crucial role in neuroimmune modulation and organ protection