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Animal LD50 studies showed toxic levels around 320 mg/kg body weight, translating to approximately 22,400 mg for a 70 kg human
These usually improve as your body adjusts
GLP-1s may additionally impact other physiological changes observed in the perimenopausal period, including vasomotor symptoms like hot flashes and night sweats, declines in bone health, and unhealthy changes in body composition (gains in fat mass and declines in muscle mass), but whether these impacts are beneficial or harmful for women's health remains unknown
68, 69 PPA and related short-chain fatty-acids (that is, butyrate and acetate) have broad effects on cellular systems
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To evaluate inter-study statistical heterogeneity, we calculated I2 parameters, with values exceeding 50% indicative of noteworthy heterogeneity
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