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The standard schedule begins at 0.3 mg weekly for four weeks, then escalates to 0.6 mg for four weeks, followed by 1.2 mg for four weeks, then 1.8 mg for four weeks, ultimately reaching the maintenance dose of 2.4 mg weekly

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Proc Natl Acad Sci U S A 93(15):79237926 Pompella A, Corti A, Paolicchi A, Giommarelli C, Zunino F (2007) Gamma-glutamyltransferase, redox regulation and cancer drug resistance