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Iron death, characterized by oxidative stress due to intracellular Fe2+ accumulation, leading to large amounts of ROS production, ultimately results in cell death (161) and contributes to various cardiovascular diseases including atherosclerosis, I/R injury, HF, myocardial infarction and adriamycin cardiomyopathy (162)

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doi: 10.1016/j.ifset.2008.08.004 157

Examples of DMARDs include methotrexate, which may also help skin symptoms

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