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Extrapolating from B12 supplementation trials of non-vegans to determine the needs of vegans is complicated by the fact that a high percentage of any small dose of B12 is absorbed and omnivores are normally receiving numerous small doses throughout the day

Disruption of the blood-brain barrier and increased leakage of specific substances, which ultimately leading to weakened cell junctions and abnormal regulation of ion concentrations, have been observed during the development and progression of epilepsy in both clinical studies and animal models

A 1,200mg IV dose produces measurable symptom relief in 4045% of users, while standard oral capsules at the same dose show no statistically significant benefit in controlled trials

synthesized in all mammalian cells, most heavily in the liver Intracellular concentration: 0.2 to 10 mM in most cell types

J.et al (2007)