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Compared to human calcitonin, salmon calcitonin also displays prolonged activation of human calcitonin receptors when tested in mammalian cell lines expressing the calcitonin receptor ( and calcitonin receptors, highlighting the possibility of targeting these receptors using a single molecule with dual-receptor agonistic properties

Looking ahead to late 2026, a wave of anticipated new therapeutic indications across a diverse range of clinical areas includes: Potential role as preventive medicines As incretin-based therapies continue to demonstrate a wide range of health benefits, interest is growing in their potential role as preventive medicines

But the SELECT trial hinted that theres more going on

Some women hit a plateau around this time

They activate different intracellular signaling cascades (cAMP/PKA pathway in fat cells vs incretin signaling in gut and brain)

Although we did not look at sex differences in discontinuation reasons, research work has shown that women experience nausea and vomiting (side effects) at 2.5-fold higher rates than men ( 11 )