Notably, in these studies, the upregulation of GPx4 has been achieved by using exogenous agents (like NVP-AUY922, Bafilomycin A1, PD151746, GsMTx4, epigallocatechin-3-gallate, total flavonoids of Engelhardia roxburghiana leaves, Lycium barbarum polysaccharide-glycoprotein, perillaldehyde, melotonin, ferulic acid, and sphingosine-1-phosphate) which either inhibit the degradation of GPx4 or increase its transcription by activating the Nrf2 [67]
Stability and antioxidant activity of food-grade phycocyanin isolated from Spirulina platensis
Sulforaphane protects against sodium valproate-induced acute liver injury
Grodsky, G
Expert consensus document
In addition, the activation of pancreatic stellate cells (PSCs) is a key mechanism for pancreatic islet fibrosis