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Rome III, a set of criteria used to diagnose functional GI disorders, describes the diagnosis of chronic constipation as constipation for at least six months as well as specific symptoms for at least three months (eg, straining with at least 25% of bowel movements, details here)

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This peptidomimetic nature is part of what enables its exceptional potency in animal models and why its effects are different from typical peptide pharmacokinetics

doi: 10.1016/j.addr.2022.114422, 47

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