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The mechanism of action of metformin can be varied and has effects beyond CI inhibition, depending on concentrations used in vitro 88
doi: 10.1093/bja/aex071 91
This allows it to pass through the blood-brain barrier making it the most bio-available, and thus most easily absorbed, form
These signals are not yet the same as definitive proof of prevention, but they are promising enough to merit discussion with your clinician if youre already a candidate for these drugs for diabetes, obesity, or cardiometabolic risk
The NO pathway is especially important in endothelial cells, as PKA activates NO synthase (NOS), which can produce more nitric acid and does result in reduced small intestine, large intestine, and colon motility
And honestly Im low key proud of it
