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It also increases the clearance of lactic acid from the muscles, which helps to delay the onset of muscle fatigue and improve exercise performance

In this Review, we summarize current preclinical and clinical evidence, showing that the riskbenefit profile of GLP1RAs remains favourable in individuals with T2DM and obesity, although caution is warranted in those with a low cardiometabolic risk, for whom the potential risks of cancer might outweigh any expected benefits

Severe gastroparesis or significant gastric motility disorders constitute another important contraindication

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His presentation was the culmination of a long and complex medical history (Fig

These comorbid conditions should warrant additional baseline/ongoing evaluation of mental health issues during this long-term therapy