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Low protein intake due to reduced appetite may also contribute to muscle loss and increased risk for sarcopenia especially among those with older age, sedentary behaviour and a lack of resistance/strength training

At the same time, recent multicenter evidence confirms that MASLD is now a major cause of non-cirrhotic HCC, emphasizing that carcinogenesis may occur even in early-stage disease

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This receptor profile produces broader metabolic effects than semaglutide or tirzepatide, including appetite suppression, improved insulin sensitivity, and enhanced fat oxidation

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The inability of the multi-agonists to restore gonadal function in PWA mice is likely due to chronic exposure to fixed concentrations of the exogenous androgen, DHT, which may limit the eventual beneficial effects of the compounds at the gonadal level, even when substantial metabolic improvements are achieved