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The observed aggregates likely result from the inherent stickiness of Syn 1103 , wherein the exposure of its hydrophobic region slows diffusion and promotes promiscuous interactions with various cellular proteins, thereby interfering with their normal functions
Garcia-Manero, G, Faderl S, Giles F, Verstovsek S, Beran M, Andreeff M , Cortes J, Thomas D, Koller C, Pierce S, Ouzonian S, Kantarjian H, Estey E
A test can provide valuable insight into how aging is impacting their antioxidant defense system and whether additional support is needed
Antioxid Redox Signal (2010) 13:120516
43,44 Glucose-6-phosphate dehydrogenase (G6PD) that exists as either an active dimer or an inactive monomer dehydrogenates G6P to yield 6-phosphogluconolactone (6-PGL) and NADPH in the first reaction
Pino, M
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