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Zinc in the Treatment of Idiopathic Sudden Sensorineural Hearing Loss
1 2 "A simple model to solve a complex drug toxicity problem"
The shared receptor families (T1Rs and T2Rs) illustrate a common evolutionary template for chemosensory signaling between the oral cavity and the gastrointestinal tract
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The drug primarily acts on metabolic pathways rather than directly influencing reproductive hormones or endometrial tissue
ATP depletion reduces the activity of the Na+/K+ATPases, promoting an increase of Na and water influx that induce edema and alteration of intracellular electrolytes homeostasis ( +2 antiporter membrane protein to pump Ca 2+ out of the cell, causing an intracellular Ca +2 overload ( 2+ levels are further augmented by the inhibition of Ca 2+ reuptake into the endoplasmic reticulum due to the ATP depletion
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