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In esophageal injury models, BPC-157 normalizes sphincter function by increasing pressure in both the lower esophageal sphincter (LES) and pyloric sphincter (PS) in animals with sphincter dysfunction, while in healthy animals the peptide demonstrates adaptive effects that maintain physiological sphincter tone

Until regulatory pathways evolve or academic institutions prioritize this research, human trial data will remain sparse

4 Hydroxocobalamin : A form of vitamin B 12 used in injectable medications, often used to treat vitamin B 12 deficiency

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CS: Investigation, Methodology, Writing original draft

It can retain its biological activity even in harsh conditions, such as during digestion or enzymatic reactions