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Temperature management strategies include: Use insulated medication travel cases with cooling packs (these are permitted through TSA checkpoints when used for medication) Consider battery-powered medication coolers for extended travel Never place medications in checked baggage where temperatures fluctuate dramatically Request refrigerator access at hotels in advance Use digital temperature monitors to verify storage conditions Protect medication from direct sunlight Upon arrival at accommodations, medications should be immediately transferred to a refrigerator

Figure S7

A study published in October in Alzheimers and Dementia found that, in patients with type 2 diabetes, semaglutide was associated with a 40% to 70% decreased risk for a first-time AD diagnosis within 3 years compared with other diabetes medications

doi: 10.1007/s13300-020-00981-0 70 RosenstockJWyshamCFrasJPKanekoSLeeCJFernndez LandLet al

Storage Requirements Stability Information Avoid freeze/thaw cyclesProtect from lightKeep refrigerated Lyophilized (powder) -20C 24+ months Reconstituted 2-8C ~30 days Research Applications About This Compound Melanogenesis research cyclic analog studied for potent melanocortin receptor activation Sexual function research investigated for effects mediated through MC3R and MC4R receptor pathways Appetite and metabolic research studied for effects on food intake and energy regulation via central melanocortin signaling Compatible with standard bacteriostatic water reconstitution use the peptide reconstitution calculator for exact draw volumes For research purposes only

Semaglutide in MASH: A Promising Step Forward With Room for Improvement