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In addition to the relevance of POP conjugation cited previously, hyperglycemia and hyperinsulinemia appear to directly inhibit glutathione synthesis (GCL), and the increased production of reactive oxygen species which accompanies diabetes further depletes GSH levels

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As compared to healthy controls, subjects with current or remitted MDD presented similarly lower mean C2 levels (Cohens d = 0.2, p 1e-4)

It is caused by a stroke of the optic nerve due to the reduction of blood flow

2000, 72 (suppl): 653S669S