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Rundle AG, Orjuela M, Mooney L, Tang D, Kim M, Calcagnotto A, Richie JP, Perera F
This cycle involves the mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) which, in islets and insulinoma cell lines, is about 50% of the level in liver
We did, however, find promising in vitro drug efficacy with potential for additive inhibitory effects by combining lapaquistat and leading anti-cryptosporidial compounds currently in the development pipeline (Fig S7D-F)
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