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Evaluation of primary study overlap To assess the potential risk of bias due to overlapping primary studies across the included meta-analyses, outcome indicators were first categorized by clinical system, and each outcome was assigned to a single system category

Missing doses or inconsistent timing can reduce effectiveness and slow weight loss progress

Undereating can lead to reduced exercise performance and increased risk of muscle wasting

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Many peptide materials are supplied in lyophilized form, and solid-state peptide literature notes that proteins and peptides are often formulated in solid state for stabilization during storage, while degradation can still occur in solid-state materials [18]