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When you eliminate fiber completely, you deprive your microbiome of its primary fuel source, which can reduce microbial diversity and contribute to gut dysbiosisan imbalance linked to conditions such as irritable bowel syndrome and other chronic illnesses
Additionally, LPS activates the STING-IRF3 pathway, inducing NLRP3 inflammasome assembly and ROS-TXNIP-dependent oxidative stress, which triggers caspase-1-mediated pyroptosis and releases IL-1/IL-18 (Li et al., 2019)
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This amount helps keep B12 levels up, vital for nerves
Molecularly, gypenosides pre-treatment reduced oxidative stress and restored the antioxidant machinery in the myocardium