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Active joint infection represents an absolute contraindication to intra-articular injection of any substance, including AOD-9604
2024 Nov 18;63(47):e202405941
For derivatization, 10 L of methoxyamine hydrochloride in pyridine (20 mg/mL) was added to each sample and then shaken at 30 C for 90 min, followed by the addition of 91 L of a fatty acid methyl ester (FAMEs) and N-methyl-N-(trimethylsilyl) trifluoroacetamide (MSTFA) mixture, which was shaken for 30 min at 37 C
Because healthy proliferating cells do not rely on sustained FOXO4p53 sequestration for survival, they are less affected in experimental models
