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According to the structures solved here and the AlphaFold3 model, two sites, i.e., Lys209 and Lys248, were in the vicinity to the bound CoA, and acetylation might therefore sterically and electrostatically interfere with CoA binding (Figs

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People who have a rare blood disorder (polycythemia vera) may infrequently have symptoms related to this disorder while taking cyanocobalamin

When injected subcutaneously, the fatty acid chain binds to serum albumin a protein that circulates in the blood with a long natural half-life