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These findings tightly link ROS and Nrf2 to ER oxidative protein folding and calcium signaling, establishing a regulatory mechanism for protein oxidative folding-Nrf2-ER calcium axis (Figure 7)

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Given its ability to activate NRF2-mediated cytoprotective mechanisms, sulforaphane has emerged as a promising candidate for therapeutic intervention in neurodegenerative and neurodevelopmental disorders

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Weight loss alone, without a documented comorbidity, is the most restricted pathway in 2026