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Even with medications and nicotine replacement therapy, it can be very difficult for some people to stop smoking, in part because they may not be ready to stop or may not want to stop right then, said Johannes

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So we did that

2025;105(3):e213916

Both MT-2 and leptin are thought to cause an increase in thyrotropin-releasing hormone (TRH) gene expression and the MC-4R pathway, stimulating a region of the brain associated with satiety and food intake

Exemplary case from study group 4 (no-treatment control)