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GSH is synthesized from cysteine, glutamate, and glycine by the ATP-dependent enzyme -glutamyl-cysteine (-GC) ligase (GCL) synthetase, which is composed of the -GC ligase catalytic subunit (GCLC), the -GC modifier subunit (GCLM), and GSH synthetase (GSS) 24
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These nanoparticles significantly improved cellular internalization via folic acid receptor-mediated endocytosis and effectively mitigated LPS- and DSS-induced inflammation by modulating the NF-B/IkBa/AP-1 and AMPK/SIRT1 signaling pathways
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Based upon studies in animals, it is expected that inhibition of CGRP would alleviate some of the mucus phenotypes in allergic asthma [39]
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