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Limit intake to 200 to 300 mg daily (about 2 to 3 cups of coffee) and cut off caffeine by 2 PM

Jacobsen H, Walendy-Gnir K, Tekin-Bubenheim N, Kouassi NM, Ben-Batalla I, Berenbrok N, Wolff M, Dos Reis VP, Zickler M, Scholl L, Gries A, Jania H, Kloetgen A, Dsedau A, Pilnitz-Stolze G, Jeridi A, Yildirim A, Fuchs H, Gailus-Durner V, Stoeger C, de Angelis MH, Manuylova T, Klingel K, Culley FJ, Behrends J, Loges S, Schneider B, Krauss-Etschmann S, Openshaw P, Gabriel G (2021) Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life

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A benchmark, expand, and calibration (BenchExCal) trial emulation approach for using real-world evidence to support indication expansions: design and process for a planned empirical evaluation

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It simply consumes valuable cold storage space that could be used for more sensitive reagents