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Kidney Protection Benefits GLP-1 drugs can help protect your kidneys in several ways: They promote sodium excretion (diuresis) They reduce protein in the urine (a sign of kidney damage) They help lower blood pressure, which reduces strain on kidneys They have anti-inflammatory effects that can protect kidney cells Research has found that liraglutide reduced the risk of kidney disease progression by 26% in people with type 2 diabetes and heart disease