doi: 10.1016/j.emc.2025.08.011 [PubMed]
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Pharmacodynamic study in DIO mice Female DIO mice with a body weight approximately 22 g received tail vein injections of either saline (Saline), scExe4 donor plasmid loaded LNP only (Donor), or scExe4 donor plasmid loaded LNP plus Cas9 plasmid loaded LNP (Donor+Cas9)
Supplementation with an olive oil rich diet (G1-P21) [132], a highly palatable food diet in females (P28-65) [133], a highly palatable food diet in both sexes (P20-84) [134] or a HFD in males (P20-84) [135] reversed the POS-induced depressive-like behavior in the FST in males at P80-87 [132] and at W10-12 [134] and in females at P54-59 [133], and in the SPT in males at P34-84 [135]
Given their glucose-lowering effects, GLP-1s have become standard of care for type 2 diabetes, supplanting other medication classes such as sulfonylureas.2 In 2023, GLP-1s represented 63% of diabetes spend, up from 38% in 2020.2 While diabetes GLP-1s will continue to account for a greater portion of spend compared to obesity, costs related to GLP-1s prescribed for obesity are expected to grow at a faster rate over the next 3 years
AOD9604 may promote fat metabolism and help preserve lean muscle mass