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Abdel-Daim MM, Abushouk AI, Alkhalf MI, Toraih EA, Fawzy MS, Ijaz H, Aleya L, Bungau SG (2018) Antagonistic effects of Spirulina platensis on diazinon-induced hemato-biochemical alterations and oxidative stress in rats

Pigmentation lightening for melanin-based dark circles requires 8-12 weeks minimum as brightening peptides and niacinamide gradually inhibit melanin production and promote hyperpigmented cell turnover

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The authors concluded that oral ingestion of 1650 mg per day for 12 weeks of collagen dipeptides significantly ameliorated several skin parameters in women aged 3060 years of age [42]