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Notably, SHMT2 is a mitochondrial enzyme contributory to one-carbon metabolism by converting serine and tetrahydrofolate (THF) into glycine for GSH synthesis and a one-carbon unit, 5,10-methylenetetrahydrofolate (5,10-CH 2 -THF), for dTTP synthesis 35 , respectively
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Hashimoto, N
Nicholson, J
The 4-Week Rule: You typically increase the dose only every 4 weeks , moving toward a maintenance dose (e.g., 1.72.4 mg) if needed and tolerated
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