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A 2024 paper in Science used optogenetics and human fMRI to identify GLP-1 receptor neurons in the dorsomedial hypothalamus as the substrate for the preingestive satiation these drugs produce the sense of fullness before you finish eating
Based on SURMOUNT-1 data analysis, tirzepatide decreased the 10-year estimated risk of ASCVD for obese or overweight patients
Prices run 60% to 80% lower than clinical alternatives
All doses demonstrated a therapeutic advantage in the Asian and non-Asian patients subgroup (Fig
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